p75NTR Mice
P75 transgenic mice overexpress the p75-neurotrophin-receptor (p75NTR), a type-I-transmembrane-receptor related to the tumor-necrosis-factor-receptor superfamily of death receptors. The p75 receptor is involved in several processes as the processing of amyloid precursor protein (APP), enhancement of axonal outgrowth, regulation of synaptic activity in the hippocampus, promotion of myelin formation and induction of cell death in neurons. There is evidence that during normal aging Abeta generation is activated by 'switching' from the TrkA to the p75NTR receptor system.
This animal model of neuronal p75NTR overexpression is suitable for studying strategies aimed to interfere with p75NTR –mediated cell death signalling.
References:
Kanning KC, Hudson M, Amieux PS, Wiley JC,
Bothwell M, Schecterson LC.
Proteolytic processing of the p75 neurotrophin receptor and two homologs generates
C-terminal fragments with signaling capability.
J Neurosci. 2003 Jul 2;23(13):5425-36.
Rabizadeh S, Oh J, Zhong LT, Yang J, Bitler CM,
Butcher LL, BredesenDE.
Induction of apoptosis by the low-affinity NGF
receptor.
Science. 1993 Jul 16;261(5119):345-8.
