β-Amyloid Injection
A reliable animal model of neurodegeneration induced by injections of ß-Amyloid (Aß) fragments into the rat hippocampus was developed and characterized. Aß1-40 or Aß1-42 fragments induce degeneration of neurons of the hippocampal CA1 subfield, and produce behavioral, neurochemical and immuno-histochemical changes resembling those occurring in Alzheimer's disease (Kowall et al., 1992; Miguel-Hidalgo et al., 1998; Alvarez et al., 1998).
This model of Alzheimer's disease is an ideal tool for the in vivo investigation of new compounds with neuroprotective potential.
