AD11 Mice
AD11 mice, developed by Ruperti F. et al., express recombinant anti-nerve growth factor (NGF) antibodies (mAB aD11). The emerging NGF deficits result in the development of age dependent neurodegeneration, which comprises several features of human AD. Capsoni S et al. report phenotypic changes in anti-NGF mice, as neurofibrillary tau pathology, tau hyperphosphorylation, beta-amyloid plaques formation, neuronal death and cholinergic deficits. Additionally to that, aged AD 11 mice exhibit impairments in visual recognition memory and spatial memory tasks.
Therefore,
AD11 mice appear to constitute a representative model especially for the
sporadic form of Alzheimer’s disease.
References:
Phenotypic knockout of nerve growth factor in adult transgenic mice reveals severe deficits in basal forebrain cholinergic neurons, cell death in the spleen, and skeletal muscle dystrophy.
J Neurosci. 2000 Apr 1;20(7):2589-601.
Capsoni S,
Ugolini G, Comparini A, Ruberti F, Berardi N, Cattaneo A.
Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic
mice.
Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6826-31.
Berardi N,
Braschi C, Capsoni S, Cattaneo A, Maffei L.
Environmental
enrichment delays the onset of memory deficits and reduces neuropathological
hallmarks in a mouse model of Alzheimer-like neurodegeneration.
J Alzheimers Dis. 2007 Jun;11(3):359-70.